Otrivin Nasal Spray Xylometazoline is a topical nasal decongestant used to relieve nasal congestion associated with colds, allergies, and sinusitis. The active ingredient, xylometazoline, is an alpha-adrenergic agonist that works by reducing the swelling of the nasal mucosa, thereby increasing the diameter of the nasal passages and improving breathing.
Pharmacological Properties
Xylometazoline is a selective alpha-2 adrenergic receptor agonist, which means it binds to specific receptors in the nasal mucosa, causing vasoconstriction and reducing blood flow to the area. This decrease in blood flow leads to a reduction in swelling and congestion, making it easier to breathe. The onset of action is typically within 5-10 minutes, and the effects can last for up to 10 hours. The vasoconstrictive properties of xylometazoline also help to reduce the production of nasal secretions, further alleviating congestion.
Indications and Usage
Otrivin Nasal Spray Xylometazoline is indicated for the relief of nasal congestion associated with colds, allergies, and sinusitis. It is not recommended for use in children under 6 years of age due to the risk of systemic absorption and potential adverse effects. Adults and children over 6 years old can use the spray as needed, up to 3 times a day, for a maximum of 7 consecutive days. Prolonged use can lead to rebound congestion, a condition where the nasal passages become dependent on the decongestant to remain open.
| Category | Xylometazoline |
|---|---|
| Chemical Name | 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline |
| Molecular Weight | 260.38 g/mol |
| Half-Life | 5-6 hours |
Contraindications and Precautions
Otrivin Nasal Spray Xylometazoline is contraindicated in patients with hypersensitivity to xylometazoline or any other ingredient in the formulation. It is also contraindicated in patients with severe hypertension, coronary artery disease, and prostatic hyperplasia. Caution should be exercised when using the spray in patients with glaucoma, thyrotoxicosis, and diabetes, as xylometazoline can exacerbate these conditions.
Adverse Effects
nasal dryness, irritation, and burning. Less common adverse effects include headache, dizziness, and insomnia. Rare but serious adverse effects include hypertension, cardiac arrhythmias, and allergic reactions.
- Nasal dryness: 10-20% of patients
- Nasal irritation: 5-10% of patients
- Headache: 2-5% of patients
- Dizziness: 1-2% of patients
Can I use Otrivin Nasal Spray Xylometazoline for more than 7 consecutive days?
+No, it is not recommended to use Otrivin Nasal Spray Xylometazoline for more than 7 consecutive days, as this can lead to rebound congestion and other adverse effects.
Can I use Otrivin Nasal Spray Xylometazoline if I have high blood pressure?
+Otrivin Nasal Spray Xylometazoline is contraindicated in patients with severe hypertension. If you have high blood pressure, you should consult your doctor before using the spray.
